Appetitive events and not aversive events activated dopamine neurons in the mesolimbic dopamine system of primates. The accumulation of substantial neuropharmacological data and recent data from electrophysiological recording studies in primates and recent theoretical modelling studies provide new significant insights into the function of these mesolimbic dopamine neurons that have important implications for psychiatry. Dopamine neurons in the dopamine system that originate in the ventral tegmental area and project to the nucleus accumbens, olfactory tubercle and frontal cortex have long been implicated in reward and motivational processes.
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